Mispa i180 Automated Chemiluminescence Immunoassay(CLIA) Analyser
The Mispa i180 is an automated chemiluminescence immunoassay system that employs direct chemiluminescence based on acridinium ester (AE) and magnetic microparticles. Because of its consistent performance, quick reporting, ease of use, and dependable outcomes, it may be completely suited to a range of medical laboratory application scenarios.
*Features :
-Throughput of 180T/Hr.
-30 refrigerated reagent positions with RFID Management
-50 sample positions
-Automatic startup and shutdown.
-Continuous reagents replacement and samples loading during the operation.
-Multiple magnetic separation technology, high-efficient Bind/Free separation
-Needle has the detection function to the liquid level, clot, and aspiration failure.
-Cuvettes loading by dumping, one-time for 1200 cuvettes. One Cuvette is used for one Test.
-First Indian IVD manufacturer to Commission in house CLIA Reagents Production line.
-Automatic Realtime mixing of Magnetic Beads
-Temperature Control of Reagents: 2- 8c
-Use cuvettes recycling to separate the solid and liquid, which will efficiently reduce the biological safety risks.
-Sample First Protocol to reduce reagent loss.
-STAT samples could be place randomly.
-convenient operation software with PC interface
-Time to the first result: 14 minutes.
-Chemical Label called Acridinium Ester to reduce the interference factors.
-Wash Buffer and Substrate can be placed inside the instrument without any temperature control.
-Advanced Photo Multiplier Tube (PMT) Module with an extensive sensing area and fast response time.
Immunoassays are a group of biochemical tests used to measure the concentration of specific molecules, such as proteins, hormones, drugs, or infectious agents (e.g., viruses or bacteria) in a biological sample. Immunoassays rely on the specificity and sensitivity of the antigen-antibody binding reaction.
Chemiluminescence immunoassay (CLIA)
Chemiluminescence (CL) is defined as the emission of electromagnetic radiation caused by a chemical reaction to produce light. Chemiluminescence immunoassay (CLIA) is an assay that combine chemiluminescence technique with immunochemical reactions.
Chemiluminescence is a chemical reaction that emits light when specific molecules interact. It is highly sensitive and precise, compared to other immunoassays.
CLIA = Chemiluminescence technique + immunochemical reactions.
CLIA utilize chemical probes which could generate light emission through chemical reaction to label the antibody. CLIA has gained increasing attention in different fields, including life science, clinical diagnosis, environmental monitoring, food safety and pharmaceutical analysis because of its high sensitivity, good specificity, wide range of applications, simple equipment, and wide linear range.
CLIA with Chemical Label
This kind of chemical with special structure can transfer to an excited state through chemical reaction. Photons would be released when the chemical fell to ground state from the excited state. The typical chemical is acridinium ester and its derivatives. Acridinium labelled compounds have 100 times stronger chemiluminescence intensity compared to luminol labelled ones, and acridinium esters have the dominant feature that they do not lose the luminescence efficiency even after binding to antigen or antibody. And the chemistry is simple that no enzyme needs to be involved.
Compatible with HIS/LIS
carry-over is less than 0.1ppm
Graphical representation of QC analysis
Lot Specific System Pack Reagents with calibrators.
Alarm indication to the operator during equipment malfunctions, process deviations and reagents expirations.
